A tandem Heck-aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines |
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| Authors: | Ke Chen Sumod A Pullarkat |
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| Affiliation: | Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. |
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| Abstract: | A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields. |
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