d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes |
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| Authors: | Laure Joly Frédéric Rosu Valérie Gabelica |
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| Affiliation: | Physical Chemistry and Mass Spectrometry Laboratory, Department of Chemistry, University of Liège, B-4000 Liège, Belgium. |
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| Abstract: | Contrasting with the common belief that d(TG(n)T) DNA sequences would form tetramolecular G-quadruplex assemblies, mass spectrometry reveals that these sequences tend to fold into G-quadruplex trimers, dimers, and eventually monomers as the G-tract length increases. The final structure also depends on the ionic strength. |
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