Metal-Free Oxidative Trifluoromethylthiolation of Terminal Alkynes with CF(3)SiMe(3) and Elemental Sulfur |
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| Authors: | Chao Chen Lingling Chu Feng-Ling Qing |
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| Institution: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science , 345 Lingling Lu, Shanghai 200032, China. |
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| Abstract: | A metal-free oxidative trifluoromethyl-thiolation of terminal alkynes using readily available CF(3)SiMe(3) and elemental sulfur at room temperature has been developed. This reaction provides an efficient and convenient method for the preparation of alkynyl trifluoromethyl sulfides bearing a wide range of functional groups. Preliminary investigation revealed that elemental sulfur instead of air acted as the oxidant. |
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