Studies in the field of 2, 1, 3-thia- and -selenadiazoles

The thiadiazole ring activates a chlorine atom in the ortho or para positions with respect to the nitro group in the nucleophilic animation of chloronitrobenzo-2, 1, 3-thiadiazoles. The action of ammonia on a chlorobenzo-2, 1, 3-thiadiazole activated by a nitro group in ethylene glycol readily leads to the replacement of the chlorine by an amino group. The resulting aminonitrobenzo-2, 1, 3-thiadiazoles have been reduced to the corresponding diamines and these have been converted into pyrazine, quinoxaline, thiadiazole, and acetic acid derivatives.