Morpholine derivatives |
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| Authors: | S. Z. Kaplan N. A. Zakharova A. S. Zvontsova N. V. Khromov-Borisov S. P. Kozhevnikov L. V. Pavlyuchenkova |
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| Affiliation: | 1. V. I. Lenin Leningrad Higher Naval-Engineering School. Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad
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| Abstract: | The β-oxide ring of 3-alkyl-3-(N-morpholinomethyl)oxacyclobutanes is opened to give methiodides or hydrohalide salts, respectively, of 2-alkyl-2-(N-morpholinomethyl)-3-halopropanol when they are heated with methyl iodide in methanol under pressure or heated with hydrohalic acids. When two morpholinomethyl groups are present in the 3 position of the oxacyclobutane ring, it is not opened. |
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