Reaction of α,α-dimethyl-γ-(1-phe nyl-3-methyl-4-pyrazolyl)- β , γ-butenolide with primary amines and ammonia

The conditions for the formation of amides of 4-keto acids, 2-oxo-5-hydroxypyrrolidlnes, 2-oxo-2,3-dihydropyrroles, or 2-oxo-5-aminotetrahydrofurans by reaction of a Δβ,γ-butenolide with primary amines were determined. The reaction with primary aliphatic amines — benzylamine and methylamine — in ethanol gives 2-oxo-5-hydroxypyrrolidines, while reaction with benzylamine in benzene gives the amide of a 4-keto acid. 2-Oxo-5-anilinotetrahydrofuran is formed in the reaction with aniline.