| Synthesis of the Biomimetic Polymer： Aliphatic Diamine and RGDS Modified Poly（d,l-lactic acid） |
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| 引用本文： | Xu Feng NIU Yuan Liang WANG Yan Feng LUO Jun PAN Li Xia GUO. Synthesis of the Biomimetic Polymer： Aliphatic Diamine and RGDS Modified Poly（d,l-lactic acid）[J]. 中国化学快报, 2005, 16(8): 1035-1038 |
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| 作者姓名： | Xu Feng NIU Yuan Liang WANG Yan Feng LUO Jun PAN Li Xia GUO |
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| 作者单位： | [1]Key Lab of Biomechanics ＆ Tissue Engineering （Chongqing University）, Ministry of Education Bioengineering College of Chongqing University, Chongqing 400044 |
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| 摘 要： | A novel poly（d, /-lactic acid） （PDLLA） based biomimetic polymer was synthesized by grafting maleic anhydride, butanediamine and arg-gly-asp-ser （RGDS） peptides onto the backbone of PDLLA, aiming to overcome the acidity and auto-accelerating degradation of PDLLA during degradation and to improve its biospecificity and biocompatibility. The synthetic copolymer was characterized by FTIR, ^13C NMR and amino acid analyzer （AAA）.
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| 关 键 词： | 聚合体 合成方法 脂肪二胺 RGDS 氨基酸 MPLA |
| 收稿时间： | 2004-10-08 |
Synthesis of the Biomimetic Polymer: Aliphatic Diamine and RGDS Modified Poly(d,l-lactic acid) |
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| Xu;Feng;NIU;Yuan;Liang;WANG;Yan;Feng;LUO;Jun;PAN;Li;Xia;GUO. Synthesis of the Biomimetic Polymer: Aliphatic Diamine and RGDS Modified Poly(d,l-lactic acid)[J]. Chinese Chemical Letters, 2005, 16(8): 1035-1038 |
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| Authors: | Xu Feng NIU Yuan Liang WANG Yan Feng LUO Jun PAN Li Xia GUO |
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| Affiliation: | Chongqing University |
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| Abstract: | A novel poly(d, l-lactic acid) (PDLLA) based biomimetic polymer was synthesized by grafting maleic anhydride, butanediamine and arg-gly-asp-ser (RGDS) peptides onto the backbone of PDLLA, aiming to overcome the acidity and auto-accelerating degradation of PDLLA during degradation and to improve its biospecificity and biocompatibility. The synthetic copolymer was characterized by FTIR, 13C NMR and amino acid analyzer (AAA). |
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| Keywords: | Poly(d l-lactic acid) maleic anhydride butanediamine arg-gly-asp-ser modification. |
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