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The regiospecific Fischer indole reaction in choline chloride.2ZnCl2 with product isolation by direct sublimation from the ionic liquid
Authors:Calderon Morales Raul  Tambyrajah Vasuki  Jenkins Paul R  Davies David L  Abbott Andrew P
Institution:The Green Chemistry Research Group, Department of Chemistry, University of Leicester, Leicester, UK.
Abstract:The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloridemiddle dot]2ZnCl(2); exclusive formation of 2,3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.
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