Effect of stereocomplex formation between enantiomeric poly(l,l-lactide) and poly(d,d-lactide) blocks on self-organization of amphiphilic poly(lactide)-block-poly(ethylene oxide) copolymers in dilute aqueous solution |
| |
| Institution: | 1. National Research Center ‘Kurchatov Institute’, 123182 Moscow, Russian Federation;2. N. S. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 117393 Moscow, Russian Federation;3. A. V. Shubnikov Institute of Crystallography, Federal Research Center ‘Crystallography and Photonics’, Russian Academy of Sciences, 119333 Moscow, Russian Federation |
| |
| Abstract: | The effect of crystallization of a hydrophobic poly(lactide) block on the self-organization of biocompatible and biodegradable amphiphilic poly(lactide)-block-poly(ethylene oxide) (PLA-b-PEO) copolymers in a dilute aqueous solution has been investigated. It was demonstrated that the co-crystallization of poly(L,L-lactide) P(L,L)LA] and poly(d,d-lactide) P(d,d)LA] chains under equimolar mixing of P(L,L)LA46-b-PEO113 and P(d,d)LA56-b-PEO113 copolymers resulted in the formation of stable and spontaneously water-redispersible stereocomplex micelles with semicrystalline P(L,L)LA/P(d,d)LA cores. It was shown that the P(L,L)LA46 / P(d,d)LA56-b-PEO113 stereo-complex micelles produced by dialysis can be potential vehicles for the anticancer agent oxaliplatin |
| |
| Keywords: | amphiphilic block copolymers poly(lactide) poly(ethylene oxide) self-organization stereocomplex formation block copolymer micelles drug delivery systems |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
