GSH responsive traditional clinical drugs probe for cancer cell fluorescence imaging and therapy |
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| Affiliation: | 1. Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo 315201, China;2. Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, China;3. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Despite the rapid development of fluorescence detection modalities for disease diagnosis, novel fluorescent molecules and probes still face with tremendous pressure to transform before employing such fluorescent tools in the clinic. Impressively, the fluorescent probes based on the traditional fluorescent dye are expected to accelerate the transformation process. Herein, methylene blue is requisitioned to design the GSH responsive probe MB-SS-CPT elaborately. The as-synthesized MB-SS-CPT provides a dramatic optical advantage for GSH detection in vitro, cell fluorescence imaging, in vivo imaging, and antitumor therapy. |
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