Nickel-catalyzed hydromonofluoromethylation of unactivated alkenes for expedient construction of primary alkyl fluorides |
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| Affiliation: | Department of Chemistry, University of Science and Technology of China, Hefei 230026, China |
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| Abstract: | A nickel-catalyzed direct hydromonofluoromethylation of unactivated olefins with industrial raw fluoroiodomethane is developed, furnishing various primary alkyl fluorides in a step-economic manner. The key factor to success is the use of pyridine-oxazoline as ligand and (MeO)2MeSiH as the hydrogen source. This transformation demonstrates high efficiency, mild conditions, good functional-group compatibility and great potential in the drug discovery. |
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