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An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation
引用本文:Cheng Jiang,Qi Dong You Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China. An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation[J]. 中国化学快报, 2007, 18(6): 647-650. DOI: 10.1016/j.cclet.2007.04.002
作者姓名:Cheng Jiang  Qi Dong You Department of Medicinal Chemistry  China Pharmaceutical University  Nanjing 210009  China
作者单位:Cheng Jiang,Qi Dong You Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China
基金项目:This work was financially supported by a grant from "The Six Top Talents" of Jiangsu Province (No.06-C-023) and Specialized Research Fund for the Doctoral Program of Higher Education P.R.C.(No.20060316006).
摘    要:An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes,β-ketoester and urea(thiourea) without solvent under the irradiation of microwave is described. Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77-94% for aromatic aldehydes) and short reaction time (3-8 min).

收稿时间:2006-12-21

An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation
Cheng Jiang,Qi Dong You. An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation[J]. Chinese Chemical Letters, 2007, 18(6): 647-650. DOI: 10.1016/j.cclet.2007.04.002
Authors:Cheng Jiang  Qi Dong You
Affiliation:Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
Abstract:An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, β-ketoester and urea(thiourea) without solvent under the irradiation of microwave is described. Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77–94% for aromatic aldehydes) and short reaction time (3–8 min).
Keywords:Biginelli reaction  3,4-Dihydropyrimidone  Microwave  Solvent-free  Formic acid
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