| An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation |
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| 作者姓名： | Cheng Jiang Qi Dong You |
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| 作者单位： | Cheng Jiang，Qi Dong You Department of Medicinal Chemistry，China Pharmaceutical University，Nanjing 210009，China |
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| 基金项目： | This work was financially supported by a grant from "The Six Top Talents" of Jiangsu Province (No.06-C-023) and Specialized Research Fund for the Doctoral Program of Higher Education P.R.C.(No.20060316006). |
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| 摘 要： | An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes,β-ketoester and urea(thiourea) without solvent under the irradiation of microwave is described. Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77-94% for aromatic aldehydes) and short reaction time (3-8 min).
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| 收稿时间： | 21 December 2006 |
An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation |
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| Cheng Jiang,Qi Dong You.An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation[J].Chinese Chemical Letters,2007,18(6):647-650. |
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| Authors: | Cheng Jiang Qi Dong You |
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| Institution: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, β-ketoester and urea(thiourea) without solvent under the irradiation of microwave is described. Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77–94% for aromatic aldehydes) and short reaction time (3–8 min). |
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| Keywords: | Biginelli reaction 3 4-Dihydropyrimidone Microwave Solvent-free Formic acid |
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