| Cu（I）-Catalyzed Synthesis of 2-Substituted Benzimidazoles from 2-lodoanilines and Amides |
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| 作者姓名： | Hua Yuan Yongxin Chen Jinli Song Chunxia Chen Baohua Chen |
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| 作者单位： | [1]State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China [2]Key Laboratory of Nonferrous Metal Chemistry andResources Utilization of Gansu Province, Lanzhou, Gansu 730000, China |
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| 基金项目： | Acknowledgement We are grateful for support of this project by the National Natural Science Foundation of China （No. J1103307） and the project of Science Foundation of Gansu Province （No. 1208RJZA266）. |
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| 摘 要： | A novel and efficient approach to the synthesis of 2-substituted benzimidazoles has been developed via CuI/DMEDA-catalyzed coupling reaction and post-cyclization with glacial acetic acid from readily available 2-iodoanilines and amides. This method is suitable for the construction of a variety of benzimidazoles in moderate to good yields under short reaction times.
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| 关 键 词： | 取代苯并咪唑 CuI 催化 合成 酰胺 偶联反应 反应时间 冰醋酸 |
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