A facile gamma-ray method for radiodegradation of bilirubin in chloroform |
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Authors: | F M Salih A E Pillay |
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Institution: | (1) Department of Clinical and Biomedical Physics, College of Medicine, Sultan Qaboos University, P.O. Box 35, Al Khoud, 123, Sultanate of Oman;(2) 123 Al Khoud Department of Chemistry, College of Science, Sultan Qaboos University Department of Chemistry, College of Science, P.O. Box 36, Al Khoud, 123, Sultanate of Oman |
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Abstract: | Kinetics and concentration profile associated with the regulated radiodegradation of bilirubin in an organic solvent were
assessed. The pure unconjugated specimen was prepared in chloroform (40.0 μM). The depletion of bilirubin was almost linear
with dose, and complete degradation was accomplished with doses in excess of 100 Gy. The method was also evaluated for the
explicit production of the long-wavelength isomer of biliverdin, which was characterized spectrometrically by an absorbance
band in the region 600–650 nm. Results including differences in air, N2 and O2 purged samples are presented to identify the atmospheric medium for optimum production of biliverdin. The process was regulated
by controlling the dose. The general rate constant of the depletion process was estimated at a dose rate of 5.67·10−2Gy·s−1. The method is a convenient substitute for light illumination studies of bilirubin.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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