Synthesis of functionalized diarylmethanes via a copper-catalyzed cross-coupling of arylmagnesium reagents with benzylic phosphates |
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Authors: | Kofink Christiane C Knochel Paul |
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Affiliation: | Department Chemie und Biochemie, Ludwig-Maximilians-Universit?t, Butenandtstrasse 5-13, 81377 Munich, Germany. |
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Abstract: | A combination of copper chloride, triethyl phosphite, and tetrabutylammonium iodide is a very efficient catalytic system for the synthesis of polyfunctionalized diarylmethanes, using the cross-coupling reaction of arylmagnesium halides with benzylic phosphates. The antibiotic Trimethoprim has been prepared using this Cu(I)-catalyzed cross-coupling in 52% overall yield (four steps). |
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