三苯基锗杂环羧酸酯的合成与表征

合成了8种三苯基锗杂环羧酸酯Ph~3GeO~2CR(R=2-呋喃、2-呋喃乙烯基、2-噻吩基、2-吡啶基、3-吡啶基、4-吡啶基、3-吲哚甲基、3-吲哚丙基)，利用元素分析、红外光谱、核磁共振氢谱和质谱表征了这些化合物的结构。体外实验表明，这些化合物对MCF-7和WiDr癌细胞具有较好的抑制活性。

Synthesis and characterication of triphenylgermanium heterocyclic carboxylates

Eight new triphenylgermanium heterocyclic carboxylates Ph~3GeO~2CR were synthesized by the reaction of triphenylgermanium chloride with sodium heterocyclic carboxylate, (Ph~3GeCl＋RCO~2Na→Ph~3GeO~2CR). Their structures were established by elementary analysis, IR, ^1H NMR and MS spectroscopy. The IR spectra showed that in complexes 1～8 the carboxyl groups were bidentate ligands. The complexes 1,3,6 and 7 give a very strong peak Ph~3Ge^+ at m/z=305 as base peak in mass spectra. The complexes (1～8) were tested in vitro against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma. They all display high activity in vitro, much better than cis-platin or triphenylgermanium chloride.