4-Hydroxy-2-quinolones 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylate |
| |
| Authors: | I V Ukrainets N L Bereznyakova G P Petyunin I A Tugaibei V B Rybakov V V Chernyshev A V Turov |
| |
| Institution: | (1) National University of Pharmacy, Kharkiv, 61002, Ukraine;(2) M. V. Lomonosov Moscow State University, Moscow, 119899, Russia;(3) Taras Shevchenko National University, Kiev, 01033, Ukraine |
| |
| Abstract: | An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido1,2-a]-pyrimidine-3-carboxylates
is proposed. According to 1H and 13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal
(at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 864–876, June, 2007. |
| |
| Keywords: | 2-aminopyridines heterocyclic tricarbonylmethane derivatives 2-hydroxy-4-oxo-4H-pyrido[1 2-a]pyrimidine-3-carboxylic acids esters X-ray analysis |
| 本文献已被 SpringerLink 等数据库收录！ |
|
