New Applications of the CD Exciton Chirality Method. Stereochemical Assignment of Organic Compounds Containing Carboxylic Acid Groups |
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Authors: | Anne?Fischbeck Nana?Bartke Email author" target="_blank">Hans-Ulrich?HumpfEmail author |
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Institution: | (1) Institut für Lebensmittelchemie, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany |
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Abstract: | Summary. CD exciton chirality methods are described for the stereochemical assignment of organic compounds containing carboxylic acid groups. Using the chromophoric combination 2-naphthoate or 2-anthroate and 9-anthrylmethyl group the absolute stereochemistry of - and -hydroxy carboxylic acids can be deduced from a single CD measurement. Furthermore, as demonstrated with cyclic and acylic dicarboxylic acids, the direct esterification of sterically hindered carboxyl groups with 2-naphthol also allows the stereochemical assignment via CD spectroscopy. |
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Keywords: | , Exciton chirality method, Circular dichroism, Carboxylic acid groups, Anthryldiazomethane, Stereochemistry, |
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