| 1-苄氧羰基-3-叔丁氧羰酰氨基氮杂环丁烷的合成工艺改进 |
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| 引用本文： | 王贤洵,周国川. 1-苄氧羰基-3-叔丁氧羰酰氨基氮杂环丁烷的合成工艺改进[J]. 合成化学, 2009, 17(2) |
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| 作者姓名： | 王贤洵 周国川 |
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| 作者单位： | 四川大学,华西药学院,四川,成都,610041;四川大学,华西药学院,四川,成都,610041 |
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| 摘 要： | 以苄胺和环氧氯丙烷为原料,经开环、关环、取代、还原、脱苄等反应合成了1-苄氧羰基-3-叔丁氧羰酰氨基氮杂环丁烷,总收率22.9%.其结构经1H NMR,13C NMR和MS表征.
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| 关 键 词： | 1-苄氧羰基-3-叔丁氧羰酰氨基氮杂环丁烷 苄胺 环氧氯丙烷 药物合成 工艺改进 |
Process Improvement on the Synthesis of 1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine |
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| WANG Xian-xun,ZHOU Guo-chuan. Process Improvement on the Synthesis of 1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine[J]. Chinese Journal of Synthetic Chemistry, 2009, 17(2) |
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| Authors: | WANG Xian-xun ZHOU Guo-chuan |
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| Affiliation: | West China School of Pharmacy;Sichuan University;Chengdu 610041;China |
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| Abstract: | 1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine in total yield of 22.9% was synthesized by the reaction of ring-opening,cyclization,substitution,reduction and debenzylation from benzylamine and epichlorohydrin.The structure was determined by 1H NMR,13C NMR and MS. |
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