Stimuli-responsive multilayer chitosan hollow microspheres via layer-by-layer assembly |
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| Authors: | Lu Chunyin Mu Bin Liu Peng |
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| Affiliation: | a State Key Laboratory of Applied Organic Chemistry, and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China |
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| Abstract: | Novel stimuli-responsive multilayer chitosan hollow microspheres with chitosan as the unique component have been fabricated by the sequential layer-by-layer electrostatic assembly technique from the sacrificial templates (polystyrene sulfonate, PSS) with chitosan (CS) as the polycation and carboxymethyl chitosan (CMCS) as the polyanion, respectively. Their hollow structure was confirmed by the TEM analysis. The DLS analysis indicated that the multilayer chitosan microcapsules were pH and ionic strength dual-responsive. Due to the biocompatibility of the single component chitosan used, the multilayer chitosan microcapsules are expected to be used in the controlled release of drugs. |
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| Keywords: | Multilayer hollow microsphere Chitosan Carboxymethyl chitosan Layer-by-layer assembly Stimuli-responsive |
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