| 6-亚甲基-17α-乙酰氧基-18-甲基-19-失碳-孕甾-4-烯-3,20-二酮的合成新方法研究 |
| |
| 引用本文： | 寻国良,廖清江. 6-亚甲基-17α-乙酰氧基-18-甲基-19-失碳-孕甾-4-烯-3,20-二酮的合成新方法研究[J]. 有机化学, 2005, 25(12): 1556-1559 |
| |
| 作者姓名： | 寻国良 廖清江 |
| |
| 作者单位： | 中国药科大学药学院,南京,210009 |
| |
| 摘 要： | 报道了16-亚甲基-17α-乙酰氧基-18-甲基-19-失碳-孕甾-4-烯-3,20-二酮的新合成方法. 以左旋18-甲基炔诺酮为原料, 通过脱水、氧化、环合、热解、环氧化、开环氧环、水解七步反应合成了目标化合物, 总收率20.0%. 其中化合物12, 13, 14, 15, 16尚未见文献报道.
|
| 关 键 词： | 16-亚甲基-17α-乙酰氧基-18-甲基-19-失碳-孕甾-4-烯-3,20-二酮 左旋18-甲基炔诺酮 合成新方法 |
| 收稿时间： | 2004-12-28 |
| 修稿时间： | 2005-06-17 |
New Synthetic Method of 16-Methylene-17α-acetoxy-18-methyl-19-norpregn-4-ene-3,20-dione |
| |
| XUN,Guo-Liang,LIAO,Qing-Jiang. New Synthetic Method of 16-Methylene-17α-acetoxy-18-methyl-19-norpregn-4-ene-3,20-dione[J]. Chinese Journal of Organic Chemistry, 2005, 25(12): 1556-1559 |
| |
| Authors: | XUN Guo-Liang LIAO Qing-Jiang |
| |
| Affiliation: | Pharmacy College, China Pharmaceutical University, Nanjing 210009 |
| |
| Abstract: | 16-Methylene-17a-acetoxy-18-methyl-19-norpregn-4-ene-3,20-dione was synthesized by using levonorgestrel as staring material, via a 7 step process including dehydration, oxidation, cyclization, ther- molysis, epoxidation, epoxy-ring opening and hydrolysis. The chemical structure of the target compound was confirmed by IR, 1H NMR, MS spectra and elemental analysis. With a total yield of 20.0%, the new steroids 12, 13, 14, 15 and 16 were never reported. |
| |
| Keywords: | 16-methylene-17a-acetoxy-18-methyl-19-norpregn-4-ene-3,20-dione levonorgestrel new syntheticmethod |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
|
点击此处可从《有机化学》下载全文 |
|
