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Palladium catalysed tandem cyclisation–anion capture. Part 8: Cascade hydrostannylation—cyclisation–anion capture and cascade hydroboration—cyclisation–anion capture on solid phase |
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| Authors: | Ronald Grigg William S. MacLachlan David T. MacPherson Visuvanathar Sridharan Selvaratnam Suganthan |
| Affiliation: | a Molecular Innovation, Diversity and Automated Synthesis (MIDAS) Centre, School of Chemistry, University of Leeds, Leeds LS2 9JT, UK b GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex CM19 5AW, UK |
| Abstract: | Up to four bonds and five stereocentres are created, in five component processes (five point diversity), utilising resin bound aryl iodides by hydroboration or hydrostannylation of alkynes, followed by cyclisation–anion capture involving Suzuki or Stille reactions. Three small libraries were prepared to validate the chemistry. |
| Keywords: | cascade reactions palladium catalysis hydrostannylation hydroboration Stille coupling Suzuki coupling cyclisation |
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