Studies toward the total synthesis of gambieric acids: convergent synthesis of the GHIJ-ring fragment having a side chain |
| |
| Authors: | Koichi TsuboneKeisuke Hashizume Haruhiko FuwaMakoto Sasaki |
| |
| Affiliation: | Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan |
| |
| Abstract: | A stereocontrolled synthesis of the GHIJ-ring fragment having a side chain of gambieric acids, which are potent antifungal polycyclic ether natural products, has been achieved. The synthesis features convergent assembly of the tetracyclic polyether skeleton by using aldol coupling and stereoselective construction of the J-ring side chain by a cerium chloride-promoted Julia-Kocienski reaction. |
| |
| Keywords: | Gambieric acids Polycyclic ethers Aldol coupling Julia-Kocienski reaction |
| 本文献已被 ScienceDirect 等数据库收录！ |
