|
|||||
|
|
Ytterbium triflate catalyzed synthesis of β-functionalized indole derivatives |
|
| Authors: | Francesco EpifanoSalvatore Genovese Ornelio RosatiSilvia Tagliapietra Caroline PelucchiniMassimo Curini |
| Institution: | a Dipartimento di Scienze del Farmaco, Università ‘G. D’Annunzio’ di Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy b Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy c Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, Torino, Italy |
| Abstract: | Ytterbium triflate was shown to be effective in promoting the synthesis of substituted indole derivatives starting from indole, aldehydes, and dimethyl malonate by a Yonemitsu-type three component reaction. The whole process was carried out in solvent-free conditions and furnished the desired adducts in 42-67% yield. |
| Keywords: | Heterogeneous catalysis Indole derivatives Multicomponent reactions Yonemitsu-type reaction Ytterbium triflate |
| 本文献已被 ScienceDirect 等数据库收录！ | |