| Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes |
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| 引用本文： | Qing Fang CHENG Xing You XU Ming Yan WANG Jun CHEW Wei Xing MA Xu Jie YANG. Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes[J]. 中国化学快报, 2006, 17(7): 887-890 |
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| 作者姓名： | Qing Fang CHENG Xing You XU Ming Yan WANG Jun CHEW Wei Xing MA Xu Jie YANG |
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| 作者单位： | Qing Fang CHENG1，2，Xing You XU1，2，Ming Yan WANG1，Jun CHEN1，Wei Xing MA，Xu Jie YANG2 1Department of Chemical Technology，Huaihai Institute of Technology，Lianyungang 222005 2Materials Chemistry Laboratory，Nanjing University of Science and Technology，Nanjing 210094 |
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| 摘 要： | The reductive coupling of carbonyl compounds catalyzed by the transition metal is an important group of carbon-carbon bond forming reaction. The pinacol coupling reaction of aldehydes is one of the most efficient methods for synthesis of vicinal diols1. L…
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| 关 键 词： | 对映选择体 频哪醇 氨基乙醇 不对称耦合 芳香醛 钛配合物 |
| 收稿时间： | 2006-01-10 |
Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes |
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| Qing Fang CHENG,Xing You XU,Ming Yan WANG,Jun CHEN,Wei Xing MA,Xu Jie YANG. Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes[J]. Chinese Chemical Letters, 2006, 17(7): 887-890 |
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| Authors: | Qing Fang CHENG Xing You XU Ming Yan WANG Jun CHEN Wei Xing MA Xu Jie YANG |
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| Abstract: | Asymmetric pinacol coupling of aromatic aldehydes with TiC14-Zn in the presence of enantiopure squaric acid amidoalcohols afforded 1,2-diols in excellent yields with high dl-diastereoselectivities and enantioselectivities in the range of 46-89% ee. Some factors influencing dl-diastereoselectivity and enantioselectivity were discussed. |
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| Keywords: | Chiral squaric acid amidoalcohol pinacol asymmetric coupling aromatic aldehyde. |
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