| 稀土－邻菲罗啉－氟尿嘧啶三元配合物的合成及表征 |
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| 引用本文： | 林纪筠,马德建,钟文远.稀土－邻菲罗啉－氟尿嘧啶三元配合物的合成及表征[J].中国稀土学报,1996(3). |
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| 作者姓名： | 林纪筠 马德建 钟文远 |
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| 作者单位： | 华东师范大学化学系，云南昭通师专 |
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| 摘 要： | 合成了七种稀土硝酸盐－邻菲罗啉（ｐｈｅｎ）－氟尿嘧啶（Ｆｕ）的三元固体配合物。分别进行了元素分析，摩尔电导率的测定和红外光谱、热重、差热分析的研究，确证该配合物的化学式为［Ｌｎ（ｐｈｅｎ）２（Ｆｕ）（ＮＯ３）］（ＮＯ３）２（Ｌｎ＝Ｙ、Ｌａ、Ｃｅ、Ｎｄ、Ｓｍ、Ｇｄ、Ｈｏ）。此外，对Ｌａ的三元配合物进行了１３Ｃ核磁共振谱的测定，并通过体外癌细胞瘤株抑制率的试验，表明配合物有明显的抗肿瘤效果。
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| 关 键 词： | 稀土，氟尿嘧啶，邻菲罗啉，三元配合物，生物活性 |
Synthesis and Characterization of Ln(NO_3)_3-phen-Fu Ternary Complexes |
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| Lin Jiyun, Ma Dejian.Synthesis and Characterization of Ln(NO_3)_3-phen-Fu Ternary Complexes[J].Journal of the Chinese Rare Earth Society,1996(3). |
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| Authors: | Lin Jiyun Ma Dejian |
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| Abstract: | A series of solid ternary complexes Ln(phen)2(Fu) (No3 ) ] (NO3 )2 (Ln = Y, La, Ce,Nd, Sm, Gd, Ho) were synthesized and characterized by elemental analyses, molar conductivity, IR and 13C NMR spectra. The preliminary biological activity in vitro indicates that lanthanum complex has a good anti-cancer activity. These complexes can be considered a model of study for the more complicated lanthanide-nucleic acid interactions. Their anti-cancer activity can be compared with that of 5-fluorouracil. |
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| Keywords: | Lanthanide ternary complex 5-fluorouracil 1 10-phenanthroline Biological activity |
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