测量组织局部血液灌注率的表面热干扰法

1日u云去正常的血液灌注是机体组织重要的生理要素之一，组织所需的氧、营养和药物靠灌注的血液来运输供应。心肌缺血（即冠心病）是当前困扰人们的发病率高的严重疾病之一。脑对血液的供应则更是敏感，脑血管的局部栓塞将导致局部脑组织缺血甚至坏死。因此，组织灌注状况的检测不仅对于生理和病理研究是重要的，对临床医学也是十分重要的。事实上，某些非缺血性疾病的治疗（例如癌瘤的热疗）过程也直接或间接地涉及到组织的灌注率。寻求一种测量组织灌注率的方法一直是人们孜孜以求的。近年来，各种测量方法的研究已有相当的发展山，其中热…

A SURFACE HEAT DISTURBANCE METHOD FOR MEASURING LOCAL TISSUE BLOOD PERFUSION RATE

A non-damage method for measuring local tissue blood perfusion rate by surface heat disturbance and its two particular embodimellts for realizing this measurement are presented in this paper. In derivation of the mathematic model, the Pennes equation is used, and two parameters-the arterial blood temperature Ta and the metabolic heat generation rate qm which are very difficult to be known their values have been eliminated. The effectiveness of the measurement method has been demonstrated by means of the quantitative measurement of tissue in vitro, the comparative measurement of animal under artificial perfusion and the dependence measurement in humam body.