Iron-sulfur cluster stability. Kinetics and mechanism of ligand-promoted cluster degradation |
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| Authors: | Wu Shu-pao Cowan J A |
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| Affiliation: | Evans Laboratory of Chemistry, Ohio State University, 100 West, 18th Ave, Columbus, OH 43210, USA. |
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| Abstract: | Reactivity studies of iron-sulfur cluster proteins with chelating ligands model the reactivity of cluster scaffold proteins such as ISU, and suggest a rate law [k(obs) = k2[ligand]n/{[ligand]n + K(D)}] consistent with formation of a pre-reaction complex between the Fe-S protein and one chelate ligand. |
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