C-linked galactosyl serine AFGP analogues as potent recrystallization inhibitors |
| |
Authors: | Liu Suhuai Ben Robert N |
| |
Institution: | Department of Chemistry, University of Ottawa, Ottawa, ON, Canada K1N6N5. |
| |
Abstract: | reaction: see text] A series of C-linked antifreeze glycoprotein analogues have been prepared to evaluate antifreeze activity as a function of distance between the carbohydrate moiety and polypeptide backbone. The building blocks for these analogues were prepared using either an olefin cross-metathesis or catalytic asymmetric hydrogenation. Analysis of antifreeze protein-specific activity revealed that only analogue 2a (n = 1) was a potent recrystallization inhibitor and thus has potential medical and industrial applications. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|