Preparation of 6-Fluoro-8-quinolinol and Related 6-Fluoroquinolines |
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Authors: | Herman Gershon Donald D Clarke Muriel Gershon |
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Institution: | (1) Department of Chemistry, Fordham University, Bronx, NY 10458-9993, USA, US;(2) New York Botanical Garden, Bronx, NY 10458-9993, USA, US |
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Abstract: | Summary. 6-Fluoro-8-quinolinol was prepared from 2-amino-5-fluorophenol by a Skraup synthesis. No synergism was observed between 5-fluoro- and 6-fluoro-8-quinolinols or between 6-fluoro- and 7-fluoro-8-quinolinols
against any of the six fungi in our test system (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichophyton mentagrophytes) in Sabouraud dextrose broth. Unlike the fluoro-8-quinolinols, the 8-quinolinols comparably substituted with chlorine or bromine did form
synergistic mixtures. This is attributed to steric factors.
Corresponding author. E-mail: clarke@fordham.edu
Received May 23, 2002; accepted May 29, 2002 |
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Keywords: | , ,6-Fluoro-8-quinolinol, Antifungal activity, |
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