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Dendritic folate rosettes as ion channels in lipid bilayers
Authors:Sakai Naomi  Kamikawa Yuko  Nishii Masayuki  Matsuoka Toru  Kato Takashi  Matile Stefan
Affiliation:Department of Organic Chemistry, University of Geneva, Geneva, Switzerland. naomi.sakai@chiorg.unige.ch
Abstract:The self-assembly of folate dendrimers into pi-stacked supramolecular rosettes is shown to produce ion channels in planar and spherical lipid bilayer membranes. The found ion channels are small, quite homogeneous, long-lived, ohmic, cation selective (Eisenman I), and blockable by the permeant cation.
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