| Abstract: | The tissue distribution of 14C-labeled DL-2-(4-(2-thienylcarbonyl) phenyl) propionic acid (suprofen) after po administration was studied in male, female, and pregnant rats by whole-body autoradiography. 14C localized rapidly in such highly vascularized tissues as liver, kidney, and lung as well as heart in rats of both sexes, but no significant uptake was found in the central nervous system. About half of the 14C in the liver and kidney was found to be unchanged suprofen; smaller amounts of 2-(4-(2-thienylhydroxymethyl)phenyl)propionic acid and 2-(4-carboxyphenyl)propionic acid were also detected. In pregnant rats, a low level was found in the uterus and placenta; the drug penetrated the fetuses to only a limited degree. No appreciable radioactivity was found in rat tissues 24 h after dosing. |
