Carboxybetaine methacrylate polymers offer robust, long-term protection against cell adhesion |
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Authors: | Mahmud Goher Huda Sabil Yang Wei Kandere-Grzybowska Kristiana Pilans Didzis Jiang Shaoyi Grzybowski Bartosz A |
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Institution: | Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA. |
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Abstract: | Films of poly(carboxybetaine methacrylate), poly(CBMA), grafted onto microetched gold slides are effective in preventing nonspecific adhesion of cells of different types. The degree of adhesion resistance is comparable to that achieved with the self-assembled monolayers, SAMs, of oligo(ethylene glycol) alkanethiolates. In sharp contrast to the SAMs, however, substrates protected with poly(CBMA) can be stored in dry state without losing their protective properties for periods up to 2 weeks. |
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