Synthesis of the benz[a]anthraquinone core of angucyclinone antibiotics |
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Authors: | Kalogerakis Aris Groth Ulrich |
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Institution: | Fachbereich Chemie, Universit?t Konstanz, Fach M-720, Universitaetsstrasse 10, 78457 Konstanz, Germany. |
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Abstract: | reaction: see text] A general method for the synthesis of benza]anthraquinones is reported. The key step is a catalytic cobalt-mediated 2+2+2]-cycloaddition of a triyne, which affords an angularly substituted tetracycle. Oxidation of this core gives the typical structure of angucyclinone antibiotics. |
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