Synthesis,chemistry, and dynamic NMR study of new atropisomeric 4-dialkylamino-5-chloro-1,2-dithiole-3-thiones |
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Authors: | García-Valverde María Pascual Ricardo Torroba Tomás |
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Institution: | Departamento de Química, Facultad de Ciencias, Universidad de Burgos, 09001 Burgos, Spain. |
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Abstract: | reaction: see text] Reaction of N-(2-phthalimidoethyl)-N-alkylisopropylamines and S(2)Cl(2) gave atropisomeric (by dynamic NMR) 4-N-(2-phthalimidoethyl)-N-alkylamino-5-chloro-1,2-dithiole-3-thiones that quantitatively cycloadded to dimethyl or diethyl acetylenedicarboxylate to give a novel class of stable thioacid chlorides, which in turn reacted with 1 or 2 equiv of secondary amines to give thioamides. |
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