1,2-cyclic sulfamidates as versatile precursors to thiomorpholines and piperazines |
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| Authors: | Williams Andrew J Chakthong Suda Gray Diane Lawrence Ron M Gallagher Timothy |
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| Institution: | School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK. |
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| Abstract: | reaction: see text] 1,2-Cyclic sulfamidates undergo regiospecific nucleophilic displacement with either methyl thioglycolate or alpha-amino esters, followed by lactamization (thermal, base-mediated, or cyanide-catalyzed), to give thiomorpholin-3-ones and piperazin-2-ones. |
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