Enhanced in vitro biocompatibility of ultrafine-grained biomedical NiTi alloy with microporous surface |
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Authors: | CY Zheng FL Nie YF Zheng Y ChengSC Wei RZ Valiev |
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Institution: | a State Key Laboratory for Turbulence and Complex System, College of Engineering, Peking University, Beijing 100871, China b Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871, China c Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China d Department of Oral and Maxillofacial Surgery, School of Stomatology, Peking University, Beijing 100081, China e Institute of Physics of Advanced Materials, Ufa State Aviation Technical University, Ufa, Russia |
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Abstract: | Bulk ultrafine-grained Ni50.8Ti49.2 alloy (UFG-NiTi) was successfully fabricated by equal-channel angular pressing (ECAP) technique in the present study, and to further improve its surface biocompatibility, surface modification techniques including sandblasting, acid etching and alkali treatment were employed to produce either irregularly roughened surface or microporous surface or hierarchical porous surface with bioactivity. The effect of the above surface treatments on the surface roughness, wettability, corrosion behavior, ion release, apatite forming ability and cytocompatibility of UFG-NiTi alloy were systematically investigated with the coarse-grained NiTi alloy as control. The pitting corrosion potential (Epit) was increased from 393 mV (SCE) to 704 mV (SCE) with sandblasting and further increased to 1539 mV (SCE) with following acid etching in HF/HNO3 solution. All the above surface treatment increased the apatite forming ability of UFG-NiTi in varying degrees when soaked them in simulated body fluid (SBF). Meanwhile, both sandblasting and acid etching could promote the cytocompatibility for osteoblasts: sandblasting enhanced cell attachment and acid etching increased cell proliferation. The different corrosion behavior, apatite forming ability and cellular response of UFG-NiTi after different surface modifications are attributed to the topography and wettability of the resulting surface oxide layer. |
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Keywords: | Ultrafine-grained alloy Surface modification Corrosion resistance Cytocompatibility |
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