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Preparation, characterization and MRI application of carboxymethyl dextran coated magnetic nanoparticles |
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| Authors: | G. LiuR.Y. Hong L. GuoY.G. Li H.Z. Li |
| Affiliation: | a College of Chemistry, Chemical Engineering and Materials Science & Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, SIP, Suzhou 215123, China b College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China c State Key Laboratory of Multi-phase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China d College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China e MRI Division, the First Affiliated Hospital of Soochow University, Suzhou 215007, China |
| Abstract: | Superparamagnetic nanoparticles functionalized with carboxymethyl dextran (CM-dextran) were synthesized by a two-step method. First, the magnetic nanoparticles (MNPs) coated with dextran (Mw ≈ 20000) were prepared by co-precipitation of Fe2+ and Fe3+ ions. Then, dextran on the surface of MNPs reacted with monochloroacetic acid (MCA) in alkaline condition. The influences of temperature and reactant concentration on the amount of -COOH on the surface of nanoparticles were systematically studied. The obtained MNPs coated with CM-dextran were stable over the entire range of pH and NaCl concentration. The MRI experiment indicated that the CM-dextran MNPs could potentially be used as MRI contrast agents for magnetic resonance molecular imaging. |
| Keywords: | Carboxymethyl dextran Monochloroacetic acid MRI Magnetic nanoparticle |
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