| Spectroscopic Study on Interaction of β-Cyclodextrin with Triprolidine Hydrochloride |
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| 引用本文： | ALI Syed Mashhood,ASMAT Fahmeena. Spectroscopic Study on Interaction of β-Cyclodextrin with Triprolidine Hydrochloride[J]. 中国化学, 2006, 24(5): 665-668. DOI: 10.1002/cjoc.200690127 |
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| 作者姓名： | ALI Syed Mashhood ASMAT Fahmeena |
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| 作者单位： | Department of Chemistry, Aligarh Muslim University, Aligarh, 202002, UP, India |
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| 基金项目： | Acknowledgements： We would like to thank Dr. Michael D. Threadgill, Department of Pharmacy and Pharmacology, University of Bath, UK, for the invaluable assistance with NMR analysis and Prof. Mike P. Williamson, Department of Molecular Biology and Biotechnology, University of Sheffield, UK, in obtaining 2D NMR spectra. We also appreciate the help of Mr. Vijay Kumar and Mr. Sujeet Kumar Pradhan, Matrix labs, India, for providing gratis of pure triprolidine hydrochloride. |
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| 摘 要： | The complexation of triprolidine hydrochloride （TRP） and β-cyclodextrin （β-CD） in deuterium oxide was investigated by 400 MHz 1^H NMR spectroscopy. The 800 MHz 2D ROESY data revealed that two 1 ：1 and one 2 ： 1 β-CD-TRP inclusion complexes were formed. Both aromatic moieties （p-tolyl and pyridyl ring） has entered into the β-CD cavity, confirming the existence of two different equilibria for 1 ： 1 inclusion complexes in which p-tolyl ring of the guest is more tightly held by the host cavity. The ROE intermolecular interactions provided the plausible structures of these 1 ： 1 and 2 ： 1 stoichiometric inclusion complexes of β-CD-triprolidine hydrochloride in solu- tion.
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| 关 键 词： | 分光镜分析 交互作用 主体-客体配合物 β-环式糊精 TRP ROESY |
| 收稿时间： | 2005-06-01 |
| 修稿时间： | 2005-06-012006-01-14 |
Spectroscopic Study on Interaction of/3-Cyclodextrin with Triprolidine Hydrochloride |
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| ALI,;Syed;Mashhood;ASMAT,;Fahmeena. Spectroscopic Study on Interaction of/3-Cyclodextrin with Triprolidine Hydrochloride[J]. Chinese Journal of Chemistry, 2006, 24(5): 665-668. DOI: 10.1002/cjoc.200690127 |
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| Authors: | ALI, Syed Mashhood ASMAT, Fahmeena |
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| Abstract: | The complexation of triprolidine hydrochloride (TRP) and β‐cyclodextrin (β‐CD) in deuterium oxide was investigated by 400 MHz 1H NMR spectroscopy. The 800 MHz 2D ROESY data revealed that two 1:1 and one 2:1 β‐CD‐TRP inclusion complexes were formed. Both aromatic moieties (p‐tolyl and pyridyl ring) has entered into the β‐CD cavity, confirming the existence of two different equilibria for 1:1 inclusion complexes in which p‐tolyl ring of the guest is more tightly held by the host cavity. The ROE intermolecular interactions provided the plausible structures of these 1:1 and 2:1 stoichiometric inclusion complexes of β‐CD‐triprolidine hydrochloride in solution. |
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| Keywords: | host‐guest complex β‐cyclodextrin triprolidine hydrochloride 1H NMR ROESY |
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