α-methyl amino acids by catalytic phase-transfer alkylations |
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| Authors: | Martin J. O&#x Donnell,Brigitte LeClef,David B. Rusterholz,Léon Ghosez,Jean-Pierre Antoine,Mirtha Navarro |
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| Affiliation: | Department of Chemistry, Indiana-Purdue University at Indianapolis, Indianapolis, IN 46223 U.S.A.;Laboratoire de Chimie Organique de Synthèse Université Catholique de Louvain, Place L. Pasteur, 1 B-1348 Louvain-la-Neuve, Belgium |
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| Abstract: | The α-methyl amino acids, α-methyl p-chlorophenylalanine, α-methyl p-tyrosine, α-methyl m-tyrosine and α-methyl DOPA have been prepared in good yields from amino ester hydrochlorides. The key step in the method is the catalytic phase-transfer alkylation of Schiff base derivatives of mono alkyl amino acids. |
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