Reaction of 4-acetoxy-1,4-benzoxazin-3-one with DNA. A possible chemical mechanism for the antifungal and mutagenic activities |
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| Authors: | Takayoshi Ishizaki Yuichi Hashimoto Koichi Shudo Toshihiko Okamoto |
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| Affiliation: | Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Tokyo, 113, Japan |
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| Abstract: | A reaction of 4-acetoxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one with DNA and nucleotides was described. The N4 position of the benzoxazinone reacted with the C8 position of the guanine residue of DNA and guanylic acid. |
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