The chemical synthesis of the RP and SP diastereomers of thymidyl(3′-5′)thymidyl 0,0-phosphorothioate |
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Authors: | Bogdan Uzna nski,Wojciech Niewiarowski,Wojciech J. Stec |
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Affiliation: | Polish Academy of Sciences, Centre of Molecular and Macromolecular Studies, Department of Bioorganic Chemistry, 90-362 tód?, Boczna 5, Poland |
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Abstract: | The synthesis and separation of diastereomere of protected thymidyl(3′–5′)thymidyl 0,0-phosphoranilidate () allowed to obtain in the stereospecific manner title compounds , whose absolute configuration at P atom was assigned enzymatically. TP(S)T diastereomers () were obtained independently via “phosphite” procedure. |
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