Synthesis of 6-alkyl and 6-aryl substituted 9-β-D-ribofuranosyl purines via the nickel catalyzed coupling of grignard reagents to 2′,3′,5′-tris-0-(t-butyldimethylsilysl)-9-β-D-ribofuranosyl-6-chloropurine

A series of 6-substituted purine nucleosides have been synthesized in moderate yield by the nickel catalyzed cross coupling reaction between alkyl- and aryl- Grignard reagents and 2′,3′,5′-tris-0-(t-butyldimethylsilyl)-9-β-$\text{D}$-ribofuranosyl-6-chloropurine.