| Synthesis and Evaluation of Aromatic DTPA-bis(amide) Gadolinium Complexes as Magnetic Resonance Imaging Contrast Agents |
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| 作者姓名： | ZHUO Ren Xi ** WEN Jie and WANG Lu |
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| 作者单位： | Department of Chemistry，Laboratory of Biomedical Materials of the State Education Commission of China，Wuhan University，Wuhan 430072 |
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| 摘 要： | ＳｙｎｔｈｅｓｉｓａｎｄＥｖａｌｕａｔｉｏｎｏｆＡｒｏｍａｔｉｃＤＴＰＡ┐ｂｉｓ（ａｍｉｄｅ）ＧａｄｏｌｉｎｉｕｍＣｏｍｐｌｅｘｅｓａｓＭａｇｎｅｔｉｃＲｅｓｏｎａｎｃｅＩｍａｇｉｎｇＣｏｎｔｒａｓｔＡｇｅｎｔｓＺＨＵＯＲｅｎ－Ｘｉ＊＊，ＷＥＮＪｉｅ...
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Synthesis and Evaluation of Aromatic DTPA bis(amide) Gadolinium Complexes as Magnetic Resonance Imaging Contrast Agents * |
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| ZHUO Ren Xi **,WEN Jie and WANG Lu.Synthesis and Evaluation of Aromatic DTPA-bis(amide) Gadolinium Complexes as Magnetic Resonance Imaging Contrast Agents[J].Chemical Research in Chinese University,1997(2). |
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| Authors: | ZHUO Ren Xi WEN Jie and WANG Lu |
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| Institution: | ZHUO Ren Xi **,WEN Jie and WANG Lu |
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| Abstract: | Five DTPA bis(amide)s have been synthesized and characterized by means of 1 H NMR , FT IR and elemental analyses. The stability constants of their Gd 3 complexes have been measured using a simple spectrophotometric method. The results show that the complexing properties of the ligands in comparison with those of DTPA are affected by converting two carboxyl groups to amide groups. The relaxation studies have shown that the relaxivity of the chelates is similar to that of Gd DTPA, indicating that in solution all the chelates have one water molecule directly coordinated to the metal ion. Only one water molecule in inner coordination sphere suggests the coordination of the carboxamide oxygen to gadolinium ion, which agrees with the FT IR results. |
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| Keywords: | Synthesis Aromatic DTPA bis(amide) Gadolinium Relaxivity |
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