| 以阿拉伯半乳聚糖为载体的磁共振成像造影剂的研究 |
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| 引用本文： | 孙国英,冯江华,景凤英,裴奉奎.以阿拉伯半乳聚糖为载体的磁共振成像造影剂的研究[J].高等学校化学学报,2002,23(10):1837-1841. |
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| 作者姓名： | 孙国英 冯江华 景凤英 裴奉奎 |
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| 作者单位： | 中国科学院长春应用化学研究所, 长春 130022 |
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| 基金项目： | 波谱与原子分子物理国家重点实验室资助，长春市科技发展计划基金 (批准号 :T15 2 0 0 4,2 0 0 0 19)资助 |
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| 摘 要： | 合成了阿拉伯半乳聚糖修饰的DTPA钆配合物,用红外光谱、元素分析、ICP-AES等手段进行了表征,用竞争性方法研究了其在水溶液中的稳定性,测试了其在水中及BSA溶液中的弛豫性能,并进行了体内成像实验.结果表明,其弛豫效率是目前临床所用造影剂Gd-DTPA的1.5～2.0倍,对肝脏和肾脏MRI信号具有良好的增强效果,是比较好的潜在磁共振成像造影剂.
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| 关 键 词： | 阿拉伯半乳聚糖 磁共振成像 造影剂 弛豫效率 |
| 文章编号： | 0251-0790(2002)10-1837-05 |
| 收稿时间： | 2001-12-26 |
Arabinogalactan as a Carrier for Contrast Agent in Magnetic Resonance Imaging |
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| SUN Guo-Ying,FENG Jiang-Hua,JING Feng-Ying,PEI Feng-Kui.Arabinogalactan as a Carrier for Contrast Agent in Magnetic Resonance Imaging[J].Chemical Research In Chinese Universities,2002,23(10):1837-1841. |
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| Authors: | SUN Guo-Ying FENG Jiang-Hua JING Feng-Ying PEI Feng-Kui |
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| Institution: | Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China |
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| Abstract: | Arabinogalactan-Gd-DTPA was synthesized by the reaction of diethylenetriaminepenta-acetic acid(DTPA) bisanhydride with polysaccharide in dry DMSO and characterized by FTIR, elemental analysis and ICP-AES. Its stability was investigated by competition with Ca2+, EDTA, DTPA. The t1-relaxivity is 8.06 mmol-1·L·s-1 in D 2O, 8.48 mmol-1·L·s-1 in 0.725 mmol·L-1 BSA, respectively. t1-weighted MR imaging of rat kidney and liver showed a remarkable enhancement post injection of Arabinogalactan-Gd-DTPA. The results indicate that the arabinogalactan-Gd-DTPA is a potential contrast agent for MRI. |
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| Keywords: | Arabinogalactan Magnetic resonance imaging Contrast agent Relaxivity |
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