Comparative analysis of the membrane-active properties of gossypol derivatives and their polymeric complexes |
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| Authors: | N. V. Gordienko M. V. Zamaraeva A. I. Gagel'gans N. I. Baram A. I. Ismailov A. Biktimirov Kh. L. Ziyaev |
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| Affiliation: | (1) Biology Faculty, Department of Biophysics, Tashkent State University, 700095 Tashkent, Vuzgorodok;(2) A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent |
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| Abstract: | It has beeen shown that water-soluble complexes of gossypol derivatives obtained by their immobilization on polyvinylpyrrolidone posses a lower membrane activity than the initial substances. The degree of interaction of the substances under investigation with biomembranes has been determined from the change in the intensity of the flourescence of I-anilinonaphthalene-8-sulfonic acid (ANS).Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 375–381, May–June, 1995. Original article submitted October 14, 1994. |
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