Efficient synthesis of thioesters and amides from aldehydes by using an intermolecular radical reaction in water |
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Authors: | Nambu Hisanori Hata Kayoko Matsugi Masato Kita Yasuyuki |
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Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. |
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Abstract: | The combination of the water-soluble radical initiator, 2,2'-azobis2-(2-imidazolin-2-yl)propane] dihydrochloride (VA-044) and the surfactant, cetyltrimethyl-ammonium bromide (CTAB), was found to be the most suitable condition for the effective and direct synthesis of useful active thioesters (pentafluorophenyl thioesters) in water. In addition, the direct amidation of aldehydes was achieved by the addition of the amines to the thioesterification reaction mixture in water. |
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Keywords: | aldehydes amidation radical reactions surfactants thioesters |
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