386 - Polarographic studies on perfluorocarbon emulsion,hemoglobin and erythrocyte as oxygen carriers |
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| Affiliation: | 1. Department of Cardiology, Concord Hospital, University of Sydney, Sydney, Australia;2. The George Institute for Global Health, Sydney Medical School, University of Sydney, Sydney, Australia;3. Sunshine Coast Clinical School, University of Queensland, Nambour General Hospital, Nambour, Australia;4. National Heart Foundation of Australia (New South Wales Division), Phillip, Australia;5. School of Medicine & Pharmacology, Sir Charles Gairdner Hospital Unit. University of Western Australia, Perth, Australia;6. Department of Cardiology, Monash Medical Centre, Melbourne, Australia;7. Department of Cardiology, Flinders University, Adelaide, Australia;8. Menzies School of Health Research, Charles Darwin University, Darwin, Australia |
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| Abstract: | The polarographic diffusion current of the O2 reduction was utilized to estimate the nature of O2 supply from O2 binding oxygen carriers. Perfluorocarbon (PFC) emulsion, hemoglobin (Hb) and erythrocyte were used as either artificial or natural oxygen carriers. The changes of O2 limiting current originated by the addition of an oxygen carrier into the electrolyte solution open or closed to the atmosphere under some restricted conditions were analyzed.It is concluded that the main rate-determining factor for O2 transport by PFC emulsion. Hb solution or erythrocyte suspension, may be attributed to the O2 diffusion inside the PFC particle, to the diffusion of O2 binding Hb in Hb solution, or to the diffusion of O2 binding Hb inside the erythrocyte, respectively. |
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