| Preparation and properties of diuridine 3',5'-boranophosphate |
| |
| 作者姓名： | 陈耀全 屈付成 张一兵 |
| |
| 作者单位： | Laboratory of Bio-organic and Natural Products Chemistry，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Laboratory of Bio-organic and Natural Products Chemistry，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Laboratory of Bio-organic and Natural Products Chemistry，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
| |
| 基金项目： | Project supported by the State Science and Technology Commission of China，the National Natural Science Foundation of China |
| |
| 摘 要： | Diuridine 3', 5'-boianophosphate has been synthesized. Its diastereomers were separated and their configurations were tentatively assigned based on the selective snake venom phosphodiesterase (SVPDE) hydrolysis. It is found that, compared to the unmodified parent compound diuridine phosphate, the nucleophilicity and the stability of the modified compounds to SVPDE are significantly enhanced.
|
Preparation and properties of diuridine 3',5'-boranophosphate |
| |
| CHEN Yaoquan QU Fucheng and ZHANG Yibing.Preparation and properties of diuridine 3'''',5''''-boranophosphate[J].Science in China(Chemistry),1996(1). |
| |
| Authors: | CHEN Yaoquan QU Fucheng and ZHANG Yibing |
| |
| Abstract: | Diuridine 3', 5'-boianophosphate has been synthesized. Its diastereomers were separated and their configurations were tentatively assigned based on the selective snake venom phosphodiesterase (SVPDE) hydrolysis. It is found that, compared to the unmodified parent compound diuridine phosphate, the nucleophilicity and the stability of the modified compounds to SVPDE are significantly enhanced. |
| |
| Keywords: | diuridine boranophosphate diastereomeric separation configuration assignment of chiral phosphorus atom stability to SVPDE catalytic hydrolysis |
| 本文献已被 CNKI 等数据库收录！ |
