Enantioselective Synthesis of β‐Blockers via Hydrolytic Kinetic Resolution of Terminal Oxiranes by Using Bimetallic Chiral {{2,2′‐[Cyclohexane‐1,2‐diylbis(nitrilomethylidyne)]bis[phenolato]}(2−)}cobalt ([Co(salen)])‐Type Complexes |
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| Authors: | Rahul?B Kawthekar Geon‐Joong Kim |
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| Institution: | 1. Department of Chemical Engineering, Inha University, Incheon, South Korea, 402751, (phone: +82‐32‐860‐7472;2. fax: +82‐32‐872‐0975) |
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| Abstract: | The synthesis of chirally pure β‐blockers was successfully achieved via hydrolytic kinetic resolution of butyl (±)‐4‐(oxiran‐2‐ylmethoxy)benzeneacetate ((±)‐ 1 ) and (±)‐4‐(oxiran‐2‐ylmethoxy)benzeneacetonitrile ((±)‐ 2 ) in the presence of bimetallic chiral Co(salen)]‐type complexes. The newly synthesized bimetallic chiral Co(salen)]‐type complexes exhibited excellent enantioselectivities of up to >98% ee in good yields (Tables 1–3). |
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| Keywords: | Catalysis β ‐Blockers Salen complexes Cobalt complexes Kinetic resolution |
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